Association between TP53 codon 72 polymorphism and risk of oral squamous cell carcinoma in Asians: A meta-analysis

Background: Several epidemiological studies have investigated the association between the TP53 codon 72 polymorphism and oral squamous cell carcinoma (OSCC) susceptibility; however, the results were inconsistent. Therefore, we perform this meta-analysis to investigate the association between them in Asians. Methods: A comprehensive search from PubMed and Embase were performed up to December 2013. Only the cases in the studies were diagnosed with OSCC by pathological methods were considered. After study selection and data extraction, an odds ratio (OR) with a 95% confidence interval (CI) was applied to assess the association, all analyses were conducted using the RevMan 5.2 software. Results: Finally eleven case-control studies involving 2298 OSCC patients and 2111 controls were included. The results indicated that there was no association between the TP53 codon 72 polymorphism and OSCC susceptibility [(OR = 0.77, 95%CI = 0.48–1.22) for Arg vs. Pro; (OR = 0.67, 95%CI = 0.31–1.43) for ArgArg vs. ProPro; (OR = 1.14, 95%CI = 0.97–1.35) for ArgPro vs. ProPro; (OR = 0.85, 95%CI = 0.53–1.34) for (ArgPro + ArgArg) vs. ProPro; and (OR = 0.34, 95%CI = 0.34–1.23) for ArgArg vs. (ProPro + ArgPro)]. However, the subgroup analysis demonstrated an association between the TP53 codon 72 polymorphism and human papillomavirus (HPV)-related OSCC patients. Although heterogeneity was detected, there was no publication bias. Conclusions: In conclusion, current result suggest that TP53 codon 72 polymorphism is not associated with OSCC in Asians who without HPV infection but might be associated with HPV-related OSCC patients.